The MYC probe is located on chromosome 8 and the IGH probe is located on chromosome 14. A 1200 Kb probe covering the MYC gene region at 8q24.21 is labeled with an orange dye, and part of chromosome 8 (CEN8) is labeled with a green dye. A 1600 Kb probe covering the IGH gene region at 14q32.33 is labeled with an aqua dye.

Detects IGH-MYC fusion for diagnosing Burkitt lymphoma and aggressive B-cell lymphomas. Serves as diagnostic, prognostic and predictive biomarker for disease risk stratification and therapy selection. Identifies “double-hit” lymphomas with concurrent IGH-MYC rearrangements showing highly aggressive clinical behavior. Essential for distinguishing lymphoma subtypes.