A 390 Kb probe covering the RB1(13q14.2) gene region is labeled with a green dye, and A 400 Kb probe covering the LAMP(13q14.2) gene region is labeled with an orange dye.

Detects 13q14 deletions, the most common cytogenetic abnormality in chronic lymphocytic leukemia (CLL), found in approximately 50% of patients. Used for prognosis assessment, as deletion size and cell percentage influence clinical outcome. Essential for identifying tumor suppressor gene alterations targeting DLEU2/MIR15A/MIR16-1 locus. Assists in risk stratification and treatment planning for CLL patients.