The D7S486/CEN7 probe is located on chromosome 7. A 310 Kb probe covering the D7S486 gene region at 7q31 is labeled with an orange dye, and part of chromosome 7 (CEN7) is labeled with a green dye.

Detects monosomy 7 and 7q deletions in myeloid malignancies including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Used for identifying copy number abnormalities at chromosome 7q31 and centromere 7 regions. Essential for diagnosing chromosomal aberrations with prognostic significance in hematologic malignancies and risk stratification.