The MDM2/CEN12 probe is located on chromosome 12. A 600 Kb probe covering the MDM2 gene region at 12q15 is labeled with an orange dye, and part of chromosome 12 (CEN12) is labeled with a green dye.
TP53 tumor suppressor regulates cell cycle and apoptosis. MDM2 negatively regulates p53 and is amplified in 7% of cancers (20% in soft tissue tumors). MDM2 amplification distinguishes well-differentiated/dedifferentiated liposarcomas from benign lipomatous tumors via FISH analysis.
| Product Description | Catalog No. | Specification | Certificate | Storage |
|---|---|---|---|---|
| MDM2 FISH Probe Kit | JLB401043-5 | 5 Tests | CE, ASR | Below 5°F (-15°C) |
| MDM2 FISH Probe Kit | JLB401043-10 | 10 Tests | CE, ASR | Below 5°F (-15°C) |
| MDM2 FISH Probe Kit | JLB401043-20 | 20 Tests | CE, ASR | Below 5°F (-15°C) |
